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We're searching for answers to some of childhood's diseases, conditions and issues.In addition to our four research focus areas (Aboriginal Health, Brain and Behaviour, Chronic and Severe Diseases, Early Environment), you can also discover more about specific research we're involved in and the technology we use.A total of 43 ADHD children and their parents were genotyped for the DAT1 30 variable number of tandem repeats polymorphism.
One aspect of the attention deficit in ADHD includes a subtle inattention to left space, resembling that seen after right cerebral hemisphere damage.
Since left-sided inattention in ADHD may resolve when treated with MPH, we asked whether left-sided inattention in ADHD was related to DAT1 genotype and the therapeutic efficacy of MPH.
Although no immediate cure is in sight for it, a better understanding of ADHD through the research programmes gives us all more information on the role of the brain and effective treatments for the disorder. Robertson a School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland b Schools of Psychiatry and Genetics and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland c Cognitive Neurophysiology Laboratory, Nathan S.
Neuropsychologia 45 (2007), 630-638 Response variability in Attention Deficit Hyperactivity Disorder: Evidence for neuropsychological heterogeneity Katherine A. Kline Institute, Orangeburg, NY 10962, United States d Cognitive Neuroscience Laboratory, School of Behavioural Science, University of Melbourne, Australia Abstract Response time (RT) variability is a common finding in ADHD research.
A fixed-sequence Sustained Attention to Response Task (SART) was given to 29 control, 39 unimpaired and 24 impaired- ADHD children (impairment defined by the number of commission errors).
The response time data were analysed using the Fast Fourier Transform, to define the fast-frequency and slow-frequency contributions to overall response variability.Parents rated their child’s response to MPH retrospectively using a three-point scale (no, mediocre or very good response).Additionally, parents used a symptom checklist to rate behavior while on and off medication.RT variability may reflect frontal cortex function and may be related to deficits in sustained attention.The existence of a sustained attention deficit in ADHD has been debated, largely because of inconsistent evidence of time-on-task effects.A within-family control design determined whether asymmetry indices predicted biased transmission of 10-repeat parental DAT1 alleles and/or response to MPH.It was found that left-sided inattention predicted transmission of the 10-repeat allele from parents to probands and was associated with the severity of ADHD symptomatology.The consistently poor performance in fast-frequency variability and error rates may be due to difficulties in sustained attention that fluctuate on a trial-to-trial basis. In a fixed sequence version of the task, children were required to withhold their response to a predictably occurring no-go target (3) in a 1–9 digit sequence; in the random version the sequence was unpredictable.Keywords: Sustained attention; Response time; Fast Fourier transform; Frontal cortex; Endophenotype © 2006 Elsevier Ltd. Neuropsychlogia 45 (2007) 2234-2245 Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention Katherine A. The ADHD group showed clear deficits in response inhibition and sustained attention, through higher errors of commission and omission on both SART versions.MPH may be most efficacious in this group because it ameliorates a DAT1-mediated hypodopaminergic state.Keywords: DAT1; dopamine; ADHD; methylphenidate; attention; genetics American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 136B (2005) :81–86 DRD4 Gene Variants and Sustained Attention in Attention Deficit Hyperactivity Disorder (ADHD): Effects of Associated Alleles at the VNTR and _521 SNP Mark A.