Aids Research Paper

Research on pathogenesis and public health address two sides of the same coin and underpin the effective control of HIV-associated disease and the spread of HIV in the population.

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With unprecedented speed, antiretrovirals became available that target different steps in the HIV replication cycle, which are now effectively used in combination therapy.

Combination antiretroviral therapy also reduces the likelihood of onward HIV transmission, and HIV treatment is a crucial component of HIV prevention, in combination with public health approaches, in particular the promotion of regular HIV testing and safe practices.

Despite enormous international collaborative efforts and detailed research into neutralizing antibodies and HIV specific cellular immunity, effective immunotherapy or an efficacious vaccine are not yet available.

Major aspects of HIV infection are still not well understood, and much remains to be done to ensure affected people and communities benefit from the knowledge that has accumulated and that drives clinical and public health innovation.

Reflecting this broadened scope, HIV and AIDS wants to publish articles that deal with: 1) the pathogenesis of HIV and SIV infection and those that deal with the molecular origins of its immune activation and regulation; 2) genetics of HIV acquisition and disease; 3) HIV immunity and development of prophylactic vaccines; 4) origins and pathology of HIV associated non-AIDS diseases (for instance CVD and neuropathology) in patients on c ART and their potential for immunotherapy; 5) HIV eradication therapy; 6) behavioral, social and structural factors that affect HIV risk and prevention; 7) efficacy and effectiveness of public health and combination HIV prevention approaches; 8) successful engagement with HIV treatment and care.

HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV.In the past decade, our thinking about HIV pathogenesis has significantly changed, and it is now believed that not the loss of CD4 T cells through HIV cytopathic infection, but the chronic inflammation that HIV induces, may eventually cause immune deficiency and non-AIDS diseases such as cardiovascular disease and inflammation induced artherosclerosis.However, the virus-host interactions that differ pathologically from non-pathological HIV and SIV are still unknown."Pre-exposure prophylaxis" refers to the practice of taking some drugs before being exposed to HIV infection, and having a decreased chance of contracting HIV as a result of taking that drug.Post-exposure prophylaxis refers to taking some drugs quickly after being exposed to HIV, while the virus is in a person's body but before the virus has established itself.HIV-specific immunity does affect viral load and slows down disease progression, but eventually fails in almost all patients.Better understanding the pathogenesis of HIV in the host and the dissemination of HIV in the population are both essential to effective control of the epidemic.There are variations in the health community in recommendations on what treatment doctors should recommend for people with HIV.One question, for example, is determining when a doctor should recommend that a patient take antiretroviral drugs and what drugs a doctor may recommend.In both cases, the drugs would be the same as those used to treat persons with HIV, and the intent of taking the drugs would be to eradicate the virus before the person becomes irreversibly infected.Post-exposure prophylaxis is recommended in anticipated cases of HIV exposure, such as if a nurse somehow has blood-to-blood contact with a patient in the course of work, or if someone without HIV requests the drugs immediately after having unprotected sex with a person who might have HIV.


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